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Copyright Syntheticpages ©2001

Palladium catalysed coupling of a vinyl iodide with a terminal alkyne (Sonogashira coupling); enynes

SyntheticPage 106 (2001)
Submitted 17th Aug 2001, published 17th Aug 2001

Marco Soscia (,
A contribution from the Caddick Group, Sussex

Reaction Scheme

Chemicals Used
Hunigs base (aldrich) Pd(PPh3)4 CuI (avocado) TMSA (aldrich) DMF (distilled from CaH2)

To a deoxygenated solution of iodide (10 g, 33 mmol, 1 equiv.) in DMF (62 mL) cooled to 0oC was added diisopropylethyl amine (6.4 g, 49 mmol, 1.5 equiv.) and TMS acetylene (3.2 g, 33 mmol, 1 equiv.). The reaction mixture was seen to lighten in colour (orange to yellow). Copper iodide (280 mg, 1.48 mmol, 4.5 mol %) and Pd(PPh3)4 (758 mg, 0.66 mmol, 2 mol %) were added and stirring continued overnight at 0oC. The reaction was quenched with NH4Cl solution (40 mL) and extracted into ether (5 x 120 mL). The combined organics were washed with water (20 mL), dried (MgSO4), filtered and concentrated in vacuo leaving a brown oil. Purification of this oil was achieved by chromatography on silica gel with petrol:ether (20:1 v:v) a the eluent yielding the title product as a yellow oil (6.84 g, 76 %).

Author's Comments
Due to the reactivity of Pd(PPh3)4 it was freshly prepared prior to use and never kept for longer than a few months in the freezer as a dark colouration proceeds signifying decomposure. The reaction reaction has been scaled up to 10g with no problems.

1H: 7.3 (s, 1H), 4.3 (q, 2H, J=7.12Hz), 1.35 (t, 3H, J=7.12Hz), 0.26 (s, 9H)

Lead Reference
Myers PD, Carter R, Davies M, Elliot J, Pitterna T, Tetrahedron, 1996; 72: 104

Other References
S.Caddick, V.M.Delisser, V.E.Doyle, S.Khan, Tetrahedron,1999, 2737-2754

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